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Sustanon 250: Sustanon 250 is a combination of four testosterone esters that is hardly ever prescribed medically in the United States. It is also one of the most popular substances on the market for transgender men.What it is: According to the National LGBT Health Survey 2015 (NGLHS), approximately 9% of the U.S. adult population identifies as transgender. The use of testosterone is relatively new; it wasn't discovered until the 1960s, according to the National Institutes of Health (NIH). Most people begin on a lower dose; when people begin to increase to a higher concentration (called an "adrenal rebound" — or "rebound") it has become commonly called "exogenous testosterone" (ex-), "testosterone replacement therapy" (tren-), "testosterone therapy" (tru-), or "transsexual" (tr-).How effective it is: Exogenous testosterone therapy (which isn't currently illegal) typically consists of two testosterone esters—trenbolone acetate (TPA) and testosterone cypionate (TCE, which is an inactive but more potent form of the drug). In 2015, FDA rules require that TCP and TCE use must be labeled as "medical indications." As these are only approved as medically indicated forms of testosterone, they aren't regulated as drugs under the FDA's Prescription Drug User Fee Act (PDUFA). However, that hasn't stopped companies from marketing them as over-the-counter medications for conditions such as hair loss, erectile dysfunction, and hair growth.What it isn't (yet): If someone takes testosterone under its listed medical indications, they can be prosecuted for a misdemeanor — not a felony — according to the FDA. Currently, TCP isn't currently authorized for any FDA-approved medical treatment.What it is (still): Some research shows that as much as 80% of cisgender people who take exogenous testosterone go through "transition." Some of them begin using body hair removal products, such as beard oil or hair bleach, to make themselves appear more masculine. Others use cross-dressing as a means of expressing their gender. And while these cross-dressing techniques are no longer considered illegal, they are still considered illegal under the PDUFA.When you're on this type of testosterone, your body makes its own natural testosterone. In fact, your body naturally makes more testosterone than you do because of it: You generate more and more testosterone naturally through your diet and sex hormones—not just the ones that come from your testosterone product.Exogenous testosteroneRelated Article: